Know what's in the bottle.
Every peptide we carry, shown as the short amino-acid chain it really is. Each one comes with what the studies found and where the evidence runs out. Turn a molecule with your mouse or finger.
GHK-Cu
- Found
- Isolated from human plasma by Loren Pickart in 1973. Plasma levels fall with age.
- In studies
- In a pilot study of topical copper tripeptide on aged skin (Krüger et al.), skin got thicker, better hydrated, smoother and more elastic.
- Typical use
- Cosmetic products commonly use it at about 0.2–2%.
Palmitoyl Pentapeptide-4
- Origin
- The KTTKS sequence comes from type I procollagen. A 16-carbon palmitoyl chain helps it cross the skin's lipid barrier.
- In studies
- Robinson et al. (2005) ran a 12-week, placebo-controlled trial on photoaged facial skin and saw measurable improvement.
- On market
- Since 2000.
Acetyl Hexapeptide-8
- Origin
- A short fragment modeled on SNAP-25, a protein nerves use to signal muscles to contract.
- In studies
- Studies report smaller expression lines, better elasticity and better hydration.
- On market
- Since 2001.
- 10 cmFace
- 1 mmSkin
- 10 µmCell
- 100 nmCollagen
- ~1 nmPeptide
Getting through the skin is the hard part.
A peptide can only work on the skin if it gets past the outer barrier. That's why formulators add fatty tails like the palmitoyl chain on palmitoyl pentapeptide-4. Reviews of acetyl hexapeptide-8 name poor skin penetration as its biggest limit.
That's why we focus on the look of skin: cosmetic peptides act where you put them.
We sell cosmetics only
Sandusky Wellness sells only topical cosmetics, made to be used on skin, through the Med Spa. This library is education: it covers cosmetic peptides and research peptides, and nothing in it is for sale here.
Every claim has a source
Each fact on this page links to the study or review it came from, so you can read it yourself.
Limits up front
Many peptide studies are small and paid for by the companies that make the ingredient. We tell you when that's the case.