Selank
A synthetic heptapeptide analog of the immunomodulatory peptide tuftsin with an additional Pro-Gly-Pro sequence. Studies have investigated its anxiolytic, nootropic, and immunomodulatory properties.
From ReVia
Mechanism of Action
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic peptide combining the tuftsin sequence (Thr-Lys-Pro-Arg) with a glyproline motif (Pro-Gly-Pro) that confers enzymatic stability. Its anxiolytic mechanism involves modulation of brain-derived neurotrophic factor (BDNF) expression, enhancement of serotonergic and GABAergic neurotransmission, and inhibition of enkephalin-degrading enzymes. Selank increases BDNF mRNA expression in the hippocampus, modulates the balance of T-helper cell cytokines, and influences the expression of over 50 genes related to the immune response. It does not produce sedation, dependence, or amnesia at anxiolytic doses.
Research Applications
- Studies have investigated anxiolytic effects without sedation or cognitive impairment
- Research has examined BDNF modulation and cognitive signaling pathways
- Studies have explored immunomodulatory effects through cytokine regulation
- Research has assessed its anxiolytic receptor pharmacology in multiple study settings
Key Published Studies
Narkevich VB, et al. Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/c and C57Bl/6 mice: a comparative study. Eksp Klin Farmakol. 2008;71(5):8-12.
Key finding: Measured monoamines and their metabolites in mouse brain after selank administration, reporting strain-dependent differences in serotonin turnover.
Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003;33(7):639-643.
Key finding: Selank enhanced learning and memory signaling in conditioned avoidance tasks without producing sedation or motor impairment, distinguishing it from benzodiazepine anxiolytics.
Chemical Properties
- Type
- Peptide (heptapeptide)
Research Use Only (RUO): This page summarizes published scientific research and is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment recommendations. The compound described carries a Research Use Only designation and is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in the diagnosis, treatment, cure, or prevention of any disease. Consult qualified professionals before making any health-related decisions.